Historically, the indigenous communities of Oaxaca have considered agave and its distillate as divine gifts. Mezcal was used in religious and healing ceremonies, symbolizing a spiritual connection with the earth and the gods.

Mezcal plays a leading role in various Oaxacan festivities: Fiesta de la Virgen de los Remedios in Santiago Matatlán: Known as the "Mezcal Capital of the World," Matatlán celebrates its patron saint with contests, dances, and sporting events, where mezcal is central to community gatherings. Mezcal Fair: An annual event that showcases the cultural importance of mezcal in the region, offering tastings, workshops, and activities that allow visitors to immerse themselves in its production and diversity.

The production of mezcal in Oaxaca is a tradition passed down from generation to generation. Mezcal-producing families uphold ancestral methods, such as cooking agave in earth ovens and distilling in clay or copper stills, preserving techniques that reflect the region’s identity and cultural heritage.

Mezcal is present in key moments of Oaxacan social life, such as weddings, baptisms, and wakes, symbolizing unity and celebration. Its consumption at these events strengthens community bonds and keeps local traditions alive. These traditions reflect the deep connection between mezcal and Oaxacan culture, showcasing how this beverage transcends its role as a spirit to become a symbol of identity and historical continuity.